Lipid nanodiscs are nanoscale model membranes that mimic the natural lipid bilayer structure of cell membranes. They are composed of a small disc-shaped lipid bilayer stabilized by a belt-like structure known as a membrane scaffold protein. Lipid nanodiscs have gained popularity in biochemical and biophysical research as they provide a controlled environment to study membrane-associated proteins in a soluble and native-like state. They are particularly useful for studying membrane protein dynamics, interactions, and functions. Lipid nanodiscs have potential applications in drug discovery, structural biology, and biomaterials research.